June 22, 2026
To: Vance Clinical
From: Lumen Bio
Re: Change Order #4 — LMN-203 Protocol Amendment 2
Thank you for the change order dated above. After a line-by-line review of CO #4 against our master service agreement, original SOW, and prior approved change orders, we have identified items that require revision before we can approve.
- 1. Project management upliftREDUCE
We request a reduction. The MSA bundles project management at the Initial Term rate (§5.3) and disallows separate “Senior PM” billing for trials under 30 sites.
Requested adjustment: $52,000
- 2. Site monitoring expansionREDUCE
We request a reduction to the prior CO #2 unit rate of $2,850 per visit…